This is particularly relevant during periods of caloric deficit or increased physical activity, where the demand for energy from fat sources is higher
While this is not a year for significant new launches, we expect significant pipeline data amid a pipeline reshuffling that prioritizes higher-impact programs in immunology (Roivants TL1A) and obesity (Carmots CT-388)
It is widely distributed throughout the body, being expressed on vascular endothelial cells, T lymphocytes, the gastrointestinal tract, hepatobiliary system, kidneys, and pulmonary tract (61, 62)
Scientists now understand that beneficial bacteria help produce compounds called short-chain fatty acids (SCFAs), including butyrate, which play major roles in insulin sensitivity, satiety signaling, gut barrier integrity, and metabolic flexibility
Receptor activation triggers a phospholipase C cascade, intracellular calcium mobilisation, and downstream stimulation of growth hormone secretion from somatotroph cells