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Signs warranting immediate contact include severe nausea, persistent vomiting, abdominal pain, confusion, rapid weight loss, or hypoglycemic episodes

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Hansen et al., in their commentary on Humphrey and Lawrences paper [87], emphasized that several studies have demonstrated improvements in quality of life associated with GLP-1 RA-induced weight loss, along with health-related benefits such as enhanced cardiovascular outcomes that outweigh the impact of facial aging