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In DR, these alterations can impair retinal microvascular function

The evidence summary below is per-compound only, drawn from the Phase 3 retatrutide program and the preclinical-plus-analog MOTS-c literature

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Specifically, TNF expression was higher in NAFLD patients without iron overload than in controls, with a further elevation in NAFLD patients with iron overload, while in vitro study showed that TNF downregulated the mRNA expression of HJV and FPN in HepG2 cells [112]