While aging causes a gradual decline of physiological functions, cellular senescence is defined as a state of permanent cell cycle arrest, accompanied by distinct metabolic activity (Kuilman et al., 2010
To improve transparency, an adapted PRISMA-style flow diagram documenting identification, screening, eligibility assessment, de-duplication, and selection of the RCT evidence base and the proof-of-concept Bayesian subset is provided in the Supplementary Appendix Figure 1, together with details of the search strategy, screening process, and data extraction
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Ethical approval of studies and informed consent Not applicable
The standard starting dose is 0.2 mg per night, injected subcutaneously