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Documentation was based on information from full-text publications, including preclinical and clinical trials, meta-analyses, and reviews on this topic

For example, in a 12-day study of 5 mg daily oral linagliptin therapy in participants with type 2 diabetes, Heise et al reported mean C max and steady state exposure values of 8.32 nmol/L and 158 nmol h/L, respectively

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Estimated treatment differences between cohorts showed the semaglutide 2.4 mg cohort had significantly greater percentage ( 15.0%) and absolute reduction in weight ( 15.7 kg), greater reduction in BMI ( 4.2 kg/m 2 ), and significantly greater improvements in cardiometabolic risk factors, including SBP ( 6.7 mmHg), DBP ( 2.7 mmHg), HbA1c ( 0.5%), HDL-C (1.2 mg/dl), LDL-C ( 10.4 mg/dl), and triglycerides ( 34.3 mg/dl) at 12 months

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