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Regulation of iron and ROS, Nrf2/KEAP1 pathway, GPX4-GSH pathway, as primary targets, can make a difference through antimalarial drugs, antioxidants, iron chelators, (-)-epicatechin, etc

The molecule was characterized as a competitive inhibitor of the NNMT active site that uses nicotinamide as substrate

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Not to get too technical, but vitamin C is chemically a pro-oxidant

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