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Serum creatinine 1.5 x ULN or calculated creatinine clearance of 30 mL/min Patients must be accessible for treatment and follow-up All patients must be able to understand the investigational nature of the study and give written informed consent prior to study entry Exclusion criteria Prior bariatric surgery and/or endoscopic procedures for weight loss (e.g., intragastric balloon, sleeve gastrostomy) following diagnosis of breast cancer Treatment with a GLP-1/Glucagon receptor agonist, GIP/GLP-1/Glucagon receptor agonist, GIP/GLP receptor agonist, or any combinations with GLP-1 receptor agonist therapies within the last 3 months History of severe hypersensitivity reaction to GLP-1/Glucagon receptor agonist, GIP/GLP-1/Glucagon receptor agonist, or any combinations with GLP-1 receptor agonist therapies Insulin-dependent diabetes Has clinical evidence of diabetic retinopathy Clinical evidence or suspicion of metastatic breast cancer Current or past invasive cancers, other than breast cancer, are not allowed except for: Patients with a second synchronous primary HER2-positive or triple negative breast cancer Has an active infection requiring systemic therapy Has a known history of human immunodeficiency virus (HIV) or active or persistent hepatitis B or hepatitis C virus Has significant cardiovascular disease, such as: Has a known history of active tuberculosis Women who are pregnant or lactating
Eligibility depends on factors such as medical history, current medications, laboratory findings, and overall health profile
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