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This trend is consistent with observations in tobacco and is likely related to metal toxicity affecting pigment precursors 66,67

The most common reasons include: Gastrointestinal side effects such as nausea, vomiting and diarrhea which are the single most frequently documented reason for stopping in large health system datasets High out of pocket cost and lack of insurance coverage particularly in individuals without diabetes Medication unavailability or pharmacy supply shortages which peaked in 2023early 2024 Perceived completion of therapy once target weight is reached or weight loss plateaus Concerns about long term safety or treatment burden of injections Many cohorts show substantial discontinuation by 3 months, with further losses by 6-9 months

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We don't know much about the newer ones yet." That's why it's vital to talk with your physician, he said, adding "more communication is always better." "All questions are good questions, and I'll always provide the best information and answers I can," Dr