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During sample collection an assessment as to whether an individual was affected with konzo was conducted following the WHOs 3 main criteria for diagnosis including evidence of (1) a visible symmetric spastic abnormality of gait while walking or running, (2) a history of onset of less than 1 week followed by a nonprogressive course in a formerly healthy person, and (3) bilaterally exaggerated knee or ankle jerks without signs of disease of the spine

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Numerous studies have demonstrated that impeding IGF-1R by inhibitors or monoclonal antibodies curtails the expansion and invasion of tumor cells, augments apoptosis, and heightens the vulnerability of GBM cells to chemotherapy and radiation