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Adipocytes and bone marrow stromal cells in the TME can promote the resistance of tumor cells to ASNase treatment by supplying Gln and cysteine to leukemia cells, 348,349 and cancer-associated fibroblasts can secrete Asp to promote solid tumor growth

While the pain in mice models is induced by a viral agent, it is also feasible to observe parallels in humans, with instances of Ca 2+ /CaMKII protein involvement in patients with IC/PBS

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