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Combined Approaches (Neelakantan et al., 2022): NNMT inhibition with reduced-calorie diet produced dramatic adiposity reduction in DIO mice, normalizing metabolic parameters and establishing a distinct gut microbiome

Starting with a murine ileum explant model, the authors showed that intraluminal LPS could stimulate GLP-1 secretion and that GLP-1 secretion was rapidly increased after direct LPS stimulation of an EEC cell line (STC-1 cells)

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Dosing: MariTide's Clearest Potential Advantage If MariTide delivers comparable weight loss to retatrutide in Phase 3, monthly or potentially quarterly dosing is a genuine clinical differentiator