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However, because of the concomitant hyperinsulinemia, the liver becomes inadequately hypersensitive to GH, which further worsens the situation

That's exactly why it's included in topical skincare formulas: as an antioxidant that supports skin health and a healthier-looking glow over time, not as a tool for changing your natural complexion

Reference: Gruchlik A, Chodurek E, Dzierewicz Z

21 22 In a recent placebo-controlled trial enrolling patients with type 2 diabetes, astaxanthin (8 mg daily for 8 weeks) achieved significant reductions in serum triglycerides (156128 mg/dL), serum fructosamine (7.45.8 mol/L) and systolic blood pressure (143132 mm Hg), while significantly elevating adiponectin (3647 g/mL)

In conclusion, liver failure results in severe IGF-1 deprivation and elevated GH levels