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The synergistic combination of fats and refined carbohydrates and the destruction of the food matrix may, in some cases, accelerate the absorption of nutrients and amplify dopaminergic signaling (121)

The results of these head-to-head comparisons are summarized in many current reviews (114)

Typical monitoring might involve checking thyroid function every 3 to 6 months during active weight loss, then returning to standard annual monitoring once weight stabilizes

They have both been removed from the FDAs drug shortage list after first landing there back in 2022