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Due to the higher number of participants, this study was greatly weighted and influenced the overall results, so removing of mentioned study in sensitivity analysis changed the increasing effects of NAC on the FSH levels

Packer M, Anker SD, Butler J, Filippatos G, Pocock SJ, Carson P, et al

These evaluations were performed at baseline and after two months of treatment and included the following measures: a) anthropometric parameters [body weight and waist circumference (WC)]

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However, the study had several limitations