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Hockenbery, D.M., Oltvai, Z.N., Yin, X., Milliman, C.L

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Additionally, a systematic review emphasized the role of antioxidant therapies in mitigating reactive oxygen species (ROS) levels, reducing cellular damage, and modulating inflammation across multiple chronic conditions, including diabetes [56]

Recent targeted therapies are focusing on molecular pathways implicated in OA progression, including TGF-/ALK5 signaling, Wnt/-catenin modulation, NF-B suppression, and ferroptosis inhibition (Tian et al., 2025

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