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Most patients who experience a weight-loss plateau while taking tirzepatide have not stopped responding to the medication

In the absence of a target, structure-activity work is constrained to behavioral and EEG endpoints, which are too noisy and too downstream to discriminate between plausible mechanistic hypotheses

They may be prescribed for individuals who meet certain criteria

GLP-1 medications produce significant weight loss in clinical trials, with average results ranging from 15 to 22 percent of body weight depending on the medication and dose

doi: 10.1016/S0140-6736(97)11509-4 [DOI] [PubMed] [Google Scholar] 8