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A study published in Frontiers in Endocrinology reported that these medications may increase the risk of pregnancy complications and birth defects

68 Reduction of serum ammonia level and improvement in performance on neuropsychological testing, 69 improvement in energy levels, general functioning and well-being, and reduction of anxiety and depression, 70 reduction of physical and mental fatigue, 71 and improvement of cognitive deficits and EEG findings 71 in these studies were limited by small number of participants, high risk of bias, and low power for detection of meaningful differences between the treatment groups

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Its long-term safety has yet to be explored, but rare cases of liver toxicity have been reported