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Gastrointestinal symptoms: Diarrhea, vomiting, or abdominal pain
Highly expressed DCBLD1 can impede the autophagic degradation of glucose-6-phosphate dehydrogenase (G6PD), thereby activating the pentose phosphate pathway (PPP) and promoting the progression and metastasis of cervical cancer
Noteworthy, the in vitro binding affinity for SAR425899 at the GLP1R was ~ fivefold higher than at the GCGR
Moreover, it demonstrated enhanced efficacy in mitigating reductions in Hb and PLT levels
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