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A meta-analysis covering over 28,000 patients found that while the overall rate of GI adverse events was similar (approximately 5253% of patients in both groups), serious adverse events occurred somewhat more frequently with higher tirzepatide doses (5.37% at 1015 mg) compared to semaglutide (2.8%)

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Since Ozempic slows down digestion, certain dietary modifications may make a difference [9] : Avoid high-fat and greasy foods Choose lower-fiber options initially Limit carbonated beverages Reduce spicy food intake Minimize alcohol consumption Split meals into smaller portions Eating smaller amounts more frequently throughout the day helps prevent overwhelming the digestive system [10]

In HF, the heart loses its metabolic adaptability, which throws energy metabolism into disarray