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8 When APAP is administered at therapeutic doses under normal physiological conditions, the remaining 510% of the drug is metabolized in hepatocytes by cytochrome P450 enzymes such as CYP2E1 and CYP1A2 through phase I enzymatic reactions, resulting in the generation of the toxic reactive metabolite NAPQI (Fig

In the neonatal period, this ability may be further limited as studies in young rats demonstrated that glutamine synthetase activity is particularly low in the pre-weaning period (91, 92)

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