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Description

In vivo studies demonstrated that SeMSN(siCFL1)@P(MNs)Ang2 significantly reduces tumor growth and invasion, prolongs survival, and exhibits minimal toxicity

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Across the class, other labeled or studied concerns include gallbladder-related events, pancreatitis (rare), and, for the approved agents, a boxed warning derived from rodent thyroid C-cell tumors (a finding whose human relevance remains uncertain but which contraindicates use in people with a personal or family history of medullary thyroid carcinoma or MEN 2)

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These findings align with evidence that GLP-1 is widely expressed and secreted within the nervous system, supporting potential effects in either the central or peripheral nervous system, the researchers wrote

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