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However, oral absorption is less efficient and more variable, so the buildup to therapeutic levels may take longer

The newer STEP UP trial in 2025 looked at the higher 7.2mg dose and found average weight loss of 21% over 72 weeks

While 3-AR agonism at very high doses seems to increase BAT glucose uptake, it has failed to increase human BAT oxidative metabolism

Product quality varies significantly among manufacturers, and the actual amount of bioavailable peptide reaching target tissues may be a fraction of what the product label suggests

The dual burden of obesity and type 2 diabetes is rapidly emerging as a major public health challenge in India, said Winselow Tucker, Lilly Indias president in the statement