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Dihydrofolate reductase deficiency due to a homozygous dhfr mutation causes megaloblastic anemia and cerebral folate deficiency leading to severe neurologic disease

In naturally aged mice and in doxorubicin-treated mice, FOXO4-DRI treatment significantly improved physical fitness, restored fur density, improved renal function, and improved liver function effects attributed to the selective elimination of accumulated senescent cells

These injections are not recommended for individuals with known allergies to any ingredients or with severe hypertension

The independent ADDF review explicitly flags this theoretical cancer risk as an open question

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