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Nausea, Bloating, and Discomfort One of the most common side effects of GLP-1s is gastrointestinal discomfort including nausea, indigestion, and bloating

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Novel GLP-1R agonists currently under development include HRS9531, a dual GLP-1/GIP receptor agonist being evaluated in overweight or obese individuals with T2DM, which has shown promising results in a Phase 2 study [172]

This conversation from March 2026 was edited for clarity and length

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