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Contraindications Do Not Use If You Have a personal or family history of medullary thyroid carcinoma (MTC) Have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Have had a serious hypersensitivity reaction to tirzepatide or any component of the formulation Are pregnant, planning to become pregnant, or breastfeeding Warnings and Precautions Acute pancreatitis: Has been reported in clinical trials