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Besides lifestyle changes, drugs that help prevent muscle loss may also be used in combination with GLP-1

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Only 5.7% (2/35) of the patients receiving MTZ treatment and 40% (14/35) of the untreated patients experienced poststroke depression

Other reported adverse effects include hypersensitivity reactions (rare), antibody formation against the peptide (occurred in a significant minority of patients but generally without loss of efficacy or serious consequences), and rare cases of hypopituitarism or pituitary tumor

Tirzepatide after intensive lifestyle intervention in adults with overweight or obesity: the SURMOUNT-3 phase 3 trial