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AZD9291 (Osimertinib) Osimertinib (AZD9291) is an oral, irreversible, and mutant-selective EGFR inhibitor with IC50 of 12.92, 11.44 and 493.8 nM for Exon 19 deletion EGFR, L858R/T790M EGFR, and WT EGFR in LoVo cells, respectively

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Bottom line Gastrointestinal side effects from Ozempic, including constipation, can last from days to weeks