Datos toxicolgicos preclnicos: Los estudios de toxicidad aguda y subaguda en la rata no han evidenciado mortalidad ni toxicidad orgnica significativa, incluso a dosis ampliamente superiores a las dosis teraputicas (hasta 100 veces la dosis eficaz)
and some runs off into rivers and streams
Pouliot MC, Despres JP, Nadeau A, et al
Other proteins that bind KEAP1 and interfere with KEAP1-NRF2 interaction, promoting NRF2 accumulation and function in the nucleus, include: phosphoglycerate mutase 5 (PGAM5, a serine/threonine phosphatase related to the phosphoglycerate mutase family), which has been reported to be associated with mitochondria, so its interaction with KEAP1 may be regulated by mitochondrial signalling processes [187, 188]
Horses, Cattle, Swine and Sheep - 1 to 2 ml