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Vascular mimicry has been observed in many tumor types including melanoma [58], glioma [59], head and neck cancer [60], lung cancer [61], colorectal cancer [62] and prostate cancer [63]

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Cell experiment: Regulatory effect of IGF-1 LR3 on intestinal epithelial cell barrier Intestinal epithelial cell lines, such as Caco-2 cells and IEC-6 cells, are often used to construct in vitro barrier models