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In knee OA, clinical data suggest that GLP-1RAs improve pain and function and reduce the risk of surgical intervention

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Med Sci Sports Exerc 33:11091113 Wu TH, Yen FL, Lin LT, Tsai TR, Lin CC, Cham TM (2008) Preparation, physicochemical characterization, and antioxidant effects of quercetin nanoparticles

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It acted via non-competitive inhibition, binding to non-active sites and inducing structural rearrangements, with reduced -helical content and increased -sheet and random coil, thereby disrupting ACE function without active-site competition