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10.1021/acs.biochem.6b01093 4 BaughS

A chemical approach

The resulting peptide fragments are all below 10 kilodaltons, allowing them to cross the blood-brain barrier and exert neurotrophic effects directly in the brain

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In amphetamine-induced stereotypy models (a pre-clinical model of schizophrenia-like conditions), DSIP normalised brain metabolism and MAO activity disrupted by long-term amphetamine treatment, establishing a role for adrenergic system normalisation as a mechanism of DSIPs neuroprotective activity