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Injection site rotation for frequent dosing More injections per week means you need more injection sites to rotate through

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Moreover, we recently found that alpha-cell subpopulations with decreased expression of alpha-cell maturity markers, ARX and DNMT1 , exhibit increased expression of markers of beta-cell fate, such as MAFA , and furthermore, we find this effect in induced in human islets in response to treatment with a GLP-1R agonist (79, 80)