In an animal model, semaglutide demonstrated neuroprotective effects and improved cognitive function by inhibiting the release of inflammatory cytokines mediated by the NLRP3 inflammasome, a protein involved in regulating the innate immune system and inflammatory responses
If left untreated, these complications can progress to blindness and may necessitate limb amputations
doi:10.1016/S0140-6736(24)00469-0
In recent years, basic and clinical studies have shown that GLP-1 is closely related to lipid metabolism, and it can participate in lipid metabolism by inhibiting fat synthesis, promoting fat differentiation, enhancing cholesterol metabolism, and promoting adipose browning
The rise in popularity over a short period of time also brought product liability lawsuits against the manufacturers claiming injury with one source showing 1,997 lawsuits as of July 4 with the primary concern being gastrointestinal issues and a rising concern of NAION, an eye condition causing loss of vision
