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The most common adverse events reported with oral semaglutide were mild-to-moderate transient gastrointestinal eventsa finding consistent with the known tolerability of other available GLP-1 receptor agonists
The most common side effects nausea, mild digestive changes, and temporary fatigue typically occur during the early dose escalation phase and resolve as the body adjusts
Semaglutide slows how quickly the stomach empties, delaying digestion which can lead to bloating, nausea and vomiting
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While lower doses of semaglutide are available under other brand names, such as Ozempic (primarily used for managing type 2 diabetes), only the higher-dose Wegovy formulation is FDA-approved for weight management purposes
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