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doi:10.1038/s41392-023-01481-w Neumaier F, Zlatopolskiy BD, Neumaier B

Real-world data from a 2025 study in Diabetes, Obesity and Metabolism which looked at actual clinical patients rather than trial participants showed tirzepatide patients lost 5.3% of body weight over six months compared to 2.7% with semaglutide

An international position statement on the management of frailty in diabetes mellitus: summary of recommendations 2017

UTIs, presumably due to reduced immune cell function

In a Mayo Clinic study presented at an annual meeting of the Endocrine Society in July 2025, researchers found that, over 18 months, 40 postmenopausal women who combined the GLP-1 drug tirzepatide (used in Mounjaro and Zepbound) with hormone therapy lost an average of 17 percent of their body weight