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Intensified oxidative stress and an influx of reactive oxygen species (ROS)

Chung, J.-S., Bonkobara, M., Tomihari, M., Cruz, P

Histamine : Causes blood vessel dilation, increased mucus production, and itching Prostaglandins (particularly PGD2) : Contribute to inflammation in airways Leukotrienes : Potent contributors to airway constriction (LTC4, LTD4, LTE4) Cytokines : Signal other immune cells to join the response (IL-4, IL-5, IL-6, IL-13) Tryptase : Promotes inflammation and tissue remodeling This is why blocking just one pathway like antihistamines do often isn't enough

When administered under medical supervision, B12 injections are well-tolerated, safe, and have minimal risk of side effects

doi: 10.1111/jocd.15763