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Sustained caloric deficit leads to adipocyte lipolysis, releasing fatty acids into circulation

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For people who stop using GLP-1 weight-loss drugs such as Ozempic, gaining the weight back might be the least of their concerns

Given the reduced efficacy of GLP-1RAs on glycaemia and the reported association of genetic variation in PAM with BMI we sought to establish whether the reduced efficacy extended to effects on weight loss in the two studies (PRIBA and GSK-Harmony) where data were available following 6 months of treatment (Additional file 2: Fig

56 , and Arkal et al