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Cavallini G, Ferraretti AP, Gianaroli L, Biagiotti G, Vitali G
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In a 2008 diplomatic cable (Chemical City: Guadalajara, Jalisco and the Meth Trade), a U.S
The primary methods use epichlorohydrin as the starting material, differing in whether the chemical resolution is performed at different stages of the reaction or a chiral reagent is introduced before the reaction for asymmetric induction to obtain L-carnitine
However, its clinical application has been limited by dose-dependent gastrointestinal toxicity observed in later phase I and II clinical trials
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