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These discrepancies may result from different experimental animals, the CKD stage, diet composition, and varied participant baseline characteristics (Yokoyama et al., 2012

What researchers do not yet know Honesty about the limitations of current knowledge is important

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Mostajeran F, Tehrani HG, Rahbary B

For example, in humans, it typically takes years to develop visual field loss, and treatment typically starts long time after the onset of disease, whereas in these mice, neurodegeneration starts at 5 W (EAAC1 KO mice) or 3 W (GLAST KO mice) and the treatment was started at the onset of neurodegeneration