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They dont replace diet and lifestylethey help people implement lasting changes

[DOI] [PMC free article] [PubMed] [Google Scholar] 51.Barrera JG, Sandoval DA, D'Alessio DA, Seeley RJ

While GLP-1 physiology informs the development of therapeutic agents, the native peptide itself cannot be practically administered for disease management

While people on GLP-1s do lose a lot of weight, 15-40% of the weight lost is actually lean muscle mass

The rest of this article digs into what these drugs actually change in the body the cardiovascular benefits, the metabolic rewiring, the early signals in dementia and cancer, and what the next generation of multi-agonist peptides will look like