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The drugs work by mimicking a hormone in the body called GLP-1 that triggers an increase in the production of insulin, slows the rate at which food is digested in the stomach, and reduces appetite

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When mature IGF-I lacking any E-peptide extension was expressed virally, it failed to increase muscle mass, whereas the E-peptide-bearing IGF-IA and IGF-IB isoforms drove hypertrophy evidence that, in this system, the E-domain is necessary for the local anabolic effect rather than being an inert appendage

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Journal of Clinical Investigation, 127( 12), 42174227