Understanding why requires appreciating how weight loss itself affects thyroid function: Weight loss reduces leptin levels , which can decrease TRH (thyrotropin-releasing hormone) secretion from the hypothalamus, potentially lowering TSH Improved insulin sensitivity may alter thyroid hormone metabolism and conversion of T4 to T3 Reduced inflammation from fat loss can change the thyroid hormonal milieu Changes in body composition affect thyroid hormone distribution and binding A retrospective study of over 21,000 patients found that hypothyroid individuals using semaglutide experienced modest TSH decreases alongside weight loss
Endometriosis is a chronic inflammatory condition characterized by the presence of endometrial-like tissue outside the uterus, causing pain, inflammation, and potential fertility issues
The European Medicines Agency's European Public Assessment Report (EPAR) for Wegovy similarly does not highlight dysgeusia as a frequently observed side effect in the clinical development programme
If youre trying to decide between them, youre not alone
Long-Term Efficacy and Safety of Once-Weekly Semaglutide for Weight Loss in Patients without Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. The American Journal of Cardiology 2024
