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Genetic Predisposition in Peptide Pathways and Weight Loss Variability Genetic variation in GLP-1 receptor (GLP1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR) genes influences appetite signaling and metabolic response

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In humans, immunohistochemistry using a monoclonal antibody showed that the GLP-1 receptor protein is expressed in the pancreas, in smooth muscle cells of the kidney, lung, and gastrointestinal (GI) tract, and in myocytes of the heart [16]