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Research suggests spacing these agents optimally maximizes bioavailability and minimizes gastrointestinal stress, though individual variation is significant

Secondary outcomes included change in weight, BMI, and non-invasive measures of liver fibrosis (NAFLD Fibrosis Score, APRI, FIB-4)

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This spacing reduces potential GI stress from concurrent administration and allows providers to isolate side effects if they emerge, improving clinical transparency and dose adjustment precision

5I, S2B), indicating that inducing ferroptosis by targeting x c can increase the sensitivity of ER+ breast cancer cells in response to endocrine therapy