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The key mechanisms are: Sustained appetite suppression and reduced caloric intake Reduced dietary variety and food volume Delayed gastric emptying Gastrointestinal side effects Rapid weight loss and lean mass reduction Potential alterations in gut microbiota Each pathway contributes differently

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For your appropriate patients with diabetes TOUJEO (insulin glargine) injection 300 Units/mL may provide a different option with a 300 Unit/mL insulin glargine formulation 1 For your appropriate adult patients with diabetes SOLIQUA 100/33 (insulin glargine & lixisenatide) injection 100 Units/mL & 33 mcg/mL offers an alternative option containing Lantus and lixisenatide, a GLP-1 receptor agonist 2 Important Safety Information Important Safety Information for Lantus (insulin glargine injection) 100 Units/mL Contraindications Lantus is contraindicated during episodes of hypoglycemia and in patients with hypersensitivity to insulin glargine or any of the excipients in LANTUS

6 Conclusion Gastric cancer is the third leading cause of cancer-related death worldwide

Further trials, including long-term cardiovascular outcome studies, are ongoing to assess the safety and efficacy of tirzepatide compared to other treatments for type 2 diabetes