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Try keeping track of exactly how much vitamin B12 you are consuming on a weekly basis and promptly consult your primary care physician if you start experiencing any adverse symptoms, like trouble sleeping at night or gastrointestinal discomfort you might want to lower your dosage if nothing else but your weekly vitamin B12 consumption has changed

Freeze water in plastic containers with a couple inches (a few centimeters) of head space, as the expanding ice can break glass or overfilled containers

Cytosolic GOT1 and mitochondrial GOT2, which together comprise the malate-aspartate shuttle, interconvert oxaloacetate and aspartate using glutamate or -KG as substrates 33

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This suggests that researchers can expect similar outcomes from either compound when using equivalent dosing approaches