13 NONCLINICAL TOXICOLOGY 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility In a 2-year carcinogenicity study in CD-1 mice, subcutaneous doses of 0.3, 1 and 3 mg/kg/day [5-, 17-, and 59-fold the maximum recommended human dose (MRHD) of 1 mg/week, based on AUC] were administered to the males, and 0.1, 0.3 and 1 mg/kg/day (2-, 5-, and 17-fold MRHD) were administered to the females
GLP-1 medications are not recommended for people who: Have a personal or family history of medullary thyroid cancer Have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Are pregnant or breastfeeding Have a history of severe pancreatitis A full medical history should always be reviewed by your doctor before starting therapy
47 The crucial elements of this strategy are the length of the fatty acid chain and the position of lipidation
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