Groundbreaking research done by Fasano and colleagues, found that all cases of autoimmunity have some degree of intestinal permeability (commonly referred to as leaky gut, though if you use that term with a conventionally-trained physician, he/she may look at you like you have three heads!), a genetic predisposition, and a triggering event
Hoseini A, Namazi G, Farrokhian A, Reiner , Aghadavod E, Bahmani F, et al
"The post-translational synthesis of a polyamine-derived amino acid, hypusine, in the eukaryotic translation initiation factor 5A (eIF5A)"
( Chen, 2015 ) Histamine is metabolized or cleared from the body via two enzymes, histamine methyltransferase (HNMT) and diamine oxidase (DAO)
For polycystic kidney disease, several ferroptosis-related therapeutic drugs have been validated in animal models