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Results from this trial suggested that after 28 days of treatment, the setmelanotide group demonstrated a significant mean weight reduction of 3.48 kg from baseline, accompanied by a significant decrease in mean waist circumference of 5.83 cm

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Taken together, the observed difference between neutralizing and non-neutralizing nanobodies seems to be a combination of high affinity and specificity to the prefusion form of gB, and the targeted epitope

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