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Accumulating evidence supports the notion that the effects of GLP-1 on gastrointestinal functions are mediated through its distinct receptors on vagal nerves both in animals and man (79-81)

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When ERS occurs, GRP78 binds to misfolded proteins and dissociates from PERK, IRE1, and ATF6, activating downstream signaling pathways to inhibit DNA transcription and translation, prevent protein synthesis, and accelerate the degradation of aberrant proteins, thus regulating the adaptation of the intracellular environment

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Common causes of swollen lymph nodes during GLP-1 treatment include infections, immune conditions, or malignancy unrelated to the medication

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